2gjt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:41, 30 August 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2gjt' size='340' side='right'caption='[[2gjt]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='2gjt' size='340' side='right'caption='[[2gjt]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2gjt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJT FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2gjt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJT FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ahs|2ahs]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRO, GLEPP1, PTPU2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjt OCA], [https://pdbe.org/2gjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjt RCSB], [https://www.ebi.ac.uk/pdbsum/2gjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjt OCA], [https://pdbe.org/2gjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjt RCSB], [https://www.ebi.ac.uk/pdbsum/2gjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjt ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[https://www.uniprot.org/uniprot/PTPRO_HUMAN PTPRO_HUMAN]] Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6) [MIM:[https://omim.org/entry/614196 614196]]. NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.<ref>PMID:21722858</ref>
+
[https://www.uniprot.org/uniprot/PTPRO_HUMAN PTPRO_HUMAN] Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6) [MIM:[https://omim.org/entry/614196 614196]. NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.<ref>PMID:21722858</ref>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/PTPRO_HUMAN PTPRO_HUMAN]] Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).<ref>PMID:19167335</ref>
+
[https://www.uniprot.org/uniprot/PTPRO_HUMAN PTPRO_HUMAN] Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).<ref>PMID:19167335</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 40: Line 38:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Protein-tyrosine-phosphatase]]
+
[[Category: Arrowsmith C]]
-
[[Category: Arrowsmith, C]]
+
[[Category: Barr A]]
-
[[Category: Barr, A]]
+
[[Category: Das S]]
-
[[Category: Das, S]]
+
[[Category: Edwards A]]
-
[[Category: Delft, F von]]
+
[[Category: Eswaran J]]
-
[[Category: Edwards, A]]
+
[[Category: Knapp S]]
-
[[Category: Eswaran, J]]
+
[[Category: Niesen F]]
-
[[Category: Knapp, S]]
+
[[Category: Papagrigoriou E]]
-
[[Category: Niesen, F]]
+
[[Category: Savitsky P]]
-
[[Category: Papagrigoriou, E]]
+
[[Category: Sundstrom M]]
-
[[Category: Structural genomic]]
+
[[Category: Turnbull A]]
-
[[Category: Savitsky, P]]
+
[[Category: Ugochukwu E]]
-
[[Category: Sundstrom, M]]
+
[[Category: Weigelt J]]
-
[[Category: Turnbull, A]]
+
[[Category: Von Delft F]]
-
[[Category: Ugochukwu, E]]
+
-
[[Category: Weigelt, J]]
+
-
[[Category: Glepp1]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Ptpro]]
+
-
[[Category: Ptpu2]]
+
-
[[Category: Sgc]]
+
-
[[Category: Tyrosine phosphatase]]
+

Current revision

Crystal structure of the human receptor phosphatase PTPRO

PDB ID 2gjt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools