1mfz

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[[Image:1mfz.gif|left|200px]]
[[Image:1mfz.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mfz |SIZE=350|CAPTION= <scene name='initialview01'>1mfz</scene>, resolution 2.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1mfz", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GDX:GUANOSINE+5&#39;-(TRIHYDROGEN+DIPHOSPHATE),+P&#39;-D-MANNOPYRANOSYL+ESTER'>GDX</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/GDP-mannose_6-dehydrogenase GDP-mannose 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.132 1.1.1.132] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= AlgD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])
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-->
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|DOMAIN=
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{{STRUCTURE_1mfz| PDB=1mfz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mfz OCA], [http://www.ebi.ac.uk/pdbsum/1mfz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mfz RCSB]</span>
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}}
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'''Partially refined 2.8 A Crystal structure of GDP-mannose dehydrogenase from P. aeruginosa'''
'''Partially refined 2.8 A Crystal structure of GDP-mannose dehydrogenase from P. aeruginosa'''
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[[Category: Snook, C F.]]
[[Category: Snook, C F.]]
[[Category: Tipton, P A.]]
[[Category: Tipton, P A.]]
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[[Category: domain-swapped dimer]]
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[[Category: Domain-swapped dimer]]
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[[Category: enzyme complex with cofactor and product]]
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[[Category: Enzyme complex with cofactor and product]]
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[[Category: rossman fold]]
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[[Category: Rossman fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:59:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:15:40 2008''
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Revision as of 21:59, 2 May 2008

Image:1mfz.gif

Template:STRUCTURE 1mfz

Partially refined 2.8 A Crystal structure of GDP-mannose dehydrogenase from P. aeruginosa


Overview

The enzyme GMD from Pseudomonas aeruginosa catalyzes the committed step in the synthesis of the exopolysaccharide alginate. Alginate is a major component of P. aeruginosa biofilms that protect the bacteria from the host immune response and antibiotic therapy. The 1.55 A crystal structure of GMD in ternary complex with its cofactor NAD(H) and product GDP-mannuronic acid reveals that the enzyme forms a domain-swapped dimer with two polypeptide chains contributing to each active site. The extensive dimer interface provides multiple opportunities for intersubunit communication. Comparison of the GMD structure with that of UDP-glucose dehydrogenase reveals the structural basis of sugar binding specificity that distinguishes these two related enzyme families. The high-resolution structure of GMD provides detailed information on the active site of the enzyme and a template for structure-based inhibitor design.

About this Structure

1MFZ is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure of GDP-mannose dehydrogenase: a key enzyme of alginate biosynthesis in P. aeruginosa., Snook CF, Tipton PA, Beamer LJ, Biochemistry. 2003 Apr 29;42(16):4658-68. PMID:12705829 Page seeded by OCA on Sat May 3 00:59:08 2008

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OCA

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