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2h40

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Current revision (09:51, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2h40' size='340' side='right'caption='[[2h40]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='2h40' size='340' side='right'caption='[[2h40]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2h40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H40 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2h40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H40 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2h42|2h42]], [[2h44|2h44]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE5A, PDE5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h40 OCA], [https://pdbe.org/2h40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h40 RCSB], [https://www.ebi.ac.uk/pdbsum/2h40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h40 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h40 OCA], [https://pdbe.org/2h40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h40 RCSB], [https://www.ebi.ac.uk/pdbsum/2h40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h40 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cai, J]]
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[[Category: Cai J]]
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[[Category: Corbin, J D]]
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[[Category: Corbin JD]]
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[[Category: Francis, S H]]
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[[Category: Francis SH]]
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[[Category: Huai, Q]]
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[[Category: Huai Q]]
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[[Category: Ke, H]]
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[[Category: Ke H]]
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[[Category: Lin, G]]
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[[Category: Lin G]]
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[[Category: Liu, Y]]
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[[Category: Liu Y]]
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[[Category: Robinson, H]]
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[[Category: Robinson H]]
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[[Category: Wang, H]]
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[[Category: Wang H]]
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[[Category: Xin, Z]]
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[[Category: Xin Z]]
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[[Category: Zoraghi, R]]
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[[Category: Zoraghi R]]
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[[Category: Hydrolase]]
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[[Category: Pde5]]
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[[Category: Unliganded]]
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Current revision

Crystal structure of the catalytic domain of unliganded PDE5

PDB ID 2h40

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OCA

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