2hup

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Current revision (10:01, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2hup' size='340' side='right'caption='[[2hup]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='2hup' size='340' side='right'caption='[[2hup]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB43 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hup OCA], [https://pdbe.org/2hup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hup RCSB], [https://www.ebi.ac.uk/pdbsum/2hup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hup ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hup OCA], [https://pdbe.org/2hup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hup RCSB], [https://www.ebi.ac.uk/pdbsum/2hup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hup ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RAB43_HUMAN RAB43_HUMAN]] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17562788</ref> <ref>PMID:17684057</ref> <ref>PMID:18664496</ref> <ref>PMID:21255211</ref>
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[https://www.uniprot.org/uniprot/RAB43_HUMAN RAB43_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17562788</ref> <ref>PMID:17684057</ref> <ref>PMID:18664496</ref> <ref>PMID:21255211</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Landry, R]]
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[[Category: Landry R]]
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[[Category: Park, H]]
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[[Category: Park H]]
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[[Category: Structural genomic]]
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[[Category: Shen Y]]
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[[Category: Shen, Y]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Tempel W]]
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[[Category: Tempel, W]]
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[[Category: Wang J]]
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[[Category: Wang, J]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: G-protein]]
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[[Category: Gdp]]
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[[Category: Rab]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of human RAB43 in complex with GDP

PDB ID 2hup

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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