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2ic1

From Proteopedia

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Current revision (10:08, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2ic1' size='340' side='right'caption='[[2ic1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2ic1' size='340' side='right'caption='[[2ic1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ic1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IC1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ic1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IC1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDO1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cysteine_dioxygenase Cysteine dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.20 1.13.11.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ic1 OCA], [https://pdbe.org/2ic1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ic1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ic1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ic1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ic1 OCA], [https://pdbe.org/2ic1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ic1 RCSB], [https://www.ebi.ac.uk/pdbsum/2ic1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ic1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CDO1_HUMAN CDO1_HUMAN]] Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
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[https://www.uniprot.org/uniprot/CDO1_HUMAN CDO1_HUMAN] Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cysteine dioxygenase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Rao, Z]]
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[[Category: Rao Z]]
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[[Category: Sun, P]]
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[[Category: Sun P]]
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[[Category: Tang, D]]
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[[Category: Tang D]]
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[[Category: Wei, L]]
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[[Category: Wei L]]
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[[Category: Wu, X]]
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[[Category: Wu X]]
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[[Category: Ye, S]]
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[[Category: Ye S]]
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[[Category: Cupin]]
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[[Category: Enzyme-substrate complex]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of Human Cysteine Dioxygenase in Complex with Substrate Cysteine

PDB ID 2ic1

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OCA

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