2il1
From Proteopedia
(Difference between revisions)
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<StructureSection load='2il1' size='340' side='right'caption='[[2il1]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='2il1' size='340' side='right'caption='[[2il1]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2il1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2il1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IL1 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2il1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il1 OCA], [https://pdbe.org/2il1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2il1 RCSB], [https://www.ebi.ac.uk/pdbsum/2il1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2il1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2il1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il1 OCA], [https://pdbe.org/2il1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2il1 RCSB], [https://www.ebi.ac.uk/pdbsum/2il1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2il1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RAB12_HUMAN RAB12_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]] | *[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Landry | + | [[Category: Landry R]] |
| - | [[Category: Park | + | [[Category: Park H]] |
| - | + | [[Category: Shen Y]] | |
| - | [[Category: Shen | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Tempel W]] |
| - | [[Category: Tempel | + | [[Category: Wang J]] |
| - | [[Category: Wang | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | |
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Current revision
Crystal structure of a predicted human GTPase in complex with GDP
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bochkarev A | Edwards AM | Landry R | Park H | Shen Y | Sundstrom M | Tempel W | Wang J | Weigelt J
