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2npt
From Proteopedia
(Difference between revisions)
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<StructureSection load='2npt' size='340' side='right'caption='[[2npt]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='2npt' size='340' side='right'caption='[[2npt]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2npt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2npt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPT FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npt OCA], [https://pdbe.org/2npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npt RCSB], [https://www.ebi.ac.uk/pdbsum/2npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npt OCA], [https://pdbe.org/2npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npt RCSB], [https://www.ebi.ac.uk/pdbsum/2npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]] | *[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]] | ||
| + | *[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]] | ||
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]] | *[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]] | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Arrowsmith C]] | |
| - | [[Category: Arrowsmith | + | [[Category: Debreczeni J]] |
| - | [[Category: Debreczeni | + | [[Category: Edwards A]] |
| - | + | [[Category: Filippakopoulos P]] | |
| - | [[Category: Edwards | + | [[Category: Knapp S]] |
| - | [[Category: Filippakopoulos | + | [[Category: Papagrigoriou V]] |
| - | [[Category: Knapp | + | [[Category: Sundstrom M]] |
| - | [[Category: Papagrigoriou | + | [[Category: Turnbull A]] |
| - | + | [[Category: Von Delft F]] | |
| - | [[Category: Sundstrom | + | |
| - | [[Category: Turnbull | + | |
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Current revision
Crystal Structure of the complex of human mitogen activated protein kinase kinase 5 phox domain (MAP2K5-phox) with human mitogen activated protein kinase kinase kinase 2 phox domain (MAP3K2-phox)
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