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1mk7

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(New page: 200px<br /> <applet load="1mk7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mk7, resolution 2.20&Aring;" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 16:05, 12 November 2007

Image:1mk7.gif

1mk7, resolution 2.20Å

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CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA

Contents

Overview

The binding of cytoplasmic proteins, such as talin, to the cytoplasmic, domains of integrin adhesion receptors mediates bidirectional signal, transduction. Here we report the crystal structure of the principal, integrin binding and activating fragment of talin, alone and in complex, with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel, variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand, interaction that may be a prototype for FERM domain recognition of, transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the, integrin beta 3 tail, providing structural paradigms for integrin linkage, to the cell interior.

Disease

Known diseases associated with this structure: Glanzmann thrombasthenia, type B OMIM:[173470]

About this Structure

1MK7 is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural determinants of integrin recognition by talin., Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC, Mol Cell. 2003 Jan;11(1):49-58. PMID:12535520

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