1mhs

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[[Image:1mhs.gif|left|200px]]
[[Image:1mhs.gif|left|200px]]
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{{Structure
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|PDB= 1mhs |SIZE=350|CAPTION= <scene name='initialview01'>1mhs</scene>, resolution 8.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1mhs", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Proton-exporting_ATPase Proton-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.6 3.6.3.6] </span>
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{{STRUCTURE_1mhs| PDB=1mhs | SCENE= }}
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|RELATEDENTRY=[[1eul|1eul]], [[1iwo|1iwo]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mhs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mhs OCA], [http://www.ebi.ac.uk/pdbsum/1mhs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mhs RCSB]</span>
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'''Model of Neurospora crassa proton ATPase'''
'''Model of Neurospora crassa proton ATPase'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Kuhlbrandt, W.]]
[[Category: Kuhlbrandt, W.]]
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[[Category: active transport]]
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[[Category: Active transport]]
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[[Category: cryo-electron microscopy]]
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[[Category: Cryo-electron microscopy]]
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[[Category: ion transport]]
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[[Category: Ion transport]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: p-type atpase]]
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[[Category: P-type atpase]]
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[[Category: proton pump]]
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[[Category: Proton pump]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:03:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:13 2008''
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Revision as of 22:03, 2 May 2008

Image:1mhs.gif

Template:STRUCTURE 1mhs

Model of Neurospora crassa proton ATPase


Overview

Proton pumps in the plasma membrane of plants and yeasts maintain the intracellular pH and membrane potential. To gain insight into the molecular mechanisms of proton pumping, we built an atomic homology model of the proton pump based on the 2.6 angstrom x-ray structure of the related Ca2+ pump from rabbit sarcoplasmic reticulum. The model, when fitted to an 8 angstrom map of the Neurospora proton pump determined by electron microscopy, reveals the likely path of the proton through the membrane and shows that the nucleotide-binding domain rotates by approximately 70 degrees to deliver adenosine triphosphate (ATP) to the phosphorylation site. A synthetic peptide corresponding to the carboxyl-terminal regulatory domain stimulates ATPase activity, suggesting a mechanism for proton transport regulation.

About this Structure

1MHS is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

Structure, mechanism, and regulation of the Neurospora plasma membrane H+-ATPase., Kuhlbrandt W, Zeelen J, Dietrich J, Science. 2002 Sep 6;297(5587):1692-6. Epub 2002 Aug 8. PMID:12169656 Page seeded by OCA on Sat May 3 01:03:20 2008

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