2oil

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Current revision (10:40, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2oil' size='340' side='right'caption='[[2oil]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2oil' size='340' side='right'caption='[[2oil]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2oil]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2oil]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB25, CATX8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oil OCA], [https://pdbe.org/2oil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oil RCSB], [https://www.ebi.ac.uk/pdbsum/2oil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oil ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oil OCA], [https://pdbe.org/2oil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oil RCSB], [https://www.ebi.ac.uk/pdbsum/2oil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oil ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RAB25_HUMAN RAB25_HUMAN]] Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).<ref>PMID:15502842</ref> <ref>PMID:17925226</ref>
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[https://www.uniprot.org/uniprot/RAB25_HUMAN RAB25_HUMAN] Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).<ref>PMID:15502842</ref> <ref>PMID:17925226</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A]]
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[[Category: Bochkarev A]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Landry, R]]
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[[Category: Landry R]]
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[[Category: Park, H]]
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[[Category: Park H]]
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[[Category: Structural genomic]]
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[[Category: Shen Y]]
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[[Category: Shen, Y]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Tempel W]]
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[[Category: Tempel, W]]
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[[Category: Wang J]]
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[[Category: Wang, J]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Zhu H]]
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[[Category: Zhu, H]]
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[[Category: G-protein]]
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[[Category: Gdp]]
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[[Category: Protein transport]]
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[[Category: Rab]]
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[[Category: Sgc]]
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Current revision

Crystal structure of human RAB25 in complex with GDP

PDB ID 2oil

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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