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2oj6

From Proteopedia

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Current revision (10:40, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2oj6' size='340' side='right'caption='[[2oj6]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='2oj6' size='340' side='right'caption='[[2oj6]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus Reovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2oj6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OJ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kke|1kke]], [[2oj5|2oj5]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10891 Reovirus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [https://pdbe.org/2oj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oj6 OCA], [https://pdbe.org/2oj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2oj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oj6 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIGM1_REOVD SIGM1_REOVD] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Reovirus]]
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[[Category: Reovirus sp]]
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[[Category: Dermody, T S]]
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[[Category: Dermody TS]]
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[[Category: Kirchner, E]]
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[[Category: Kirchner E]]
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[[Category: Stehle, T]]
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[[Category: Stehle T]]
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[[Category: Aspartic acid cluster]]
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[[Category: Beta-barrel]]
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[[Category: Beta-spiral repeat]]
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[[Category: Greek key motif]]
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[[Category: Trimer]]
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[[Category: Viral protein]]
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Current revision

Crystal Structure of Reovirus T3D Attachment Protein Sigma1 head domain D345N mutant

PDB ID 2oj6

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