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2p41

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Current revision (10:53, 30 August 2023) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2p41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P41 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2p41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P41 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=G1G:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-(2-O-METHYL)-GUANOSINE'>G1G</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.801&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1l9k|1l9k]], [[2p1d|2p1d]], [[2p3l|2p3l]], [[2p3o|2p3o]], [[2p3q|2p3q]], [[2p40|2p40]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=G1G:7-METHYL-GUANOSINE-5-TRIPHOSPHATE-5-(2-O-METHYL)-GUANOSINE'>G1G</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NSP5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11060 Dengue virus 2])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p41 OCA], [https://pdbe.org/2p41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p41 RCSB], [https://www.ebi.ac.uk/pdbsum/2p41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p41 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p41 OCA], [https://pdbe.org/2p41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p41 RCSB], [https://www.ebi.ac.uk/pdbsum/2p41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p41 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9WLZ5_9FLAV Q9WLZ5_9FLAV] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[ARBA:ARBA00024317] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Egloff MP]]
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[[Category: Egloff, M P]]
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[[Category: Structural genomic]]
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[[Category: Dengue virus methyltransferase]]
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[[Category: Msgp]]
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[[Category: Transferase]]
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[[Category: Viral enzymes involved in replication]]
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[[Category: Viral protein]]
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[[Category: Vizier]]
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Current revision

Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG2'OMe and S-Adenosyl-L-homocysteine

PDB ID 2p41

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