2p7u

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<StructureSection load='2p7u' size='340' side='right'caption='[[2p7u]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='2p7u' size='340' side='right'caption='[[2p7u]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2p7u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybr Trybr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2p7u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_rhodesiense Trypanosoma brucei rhodesiense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P7U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D1R:NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE'>D1R</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rhodesain ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31286 TRYBR])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D1R:NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE'>D1R</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7u OCA], [https://pdbe.org/2p7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7u RCSB], [https://www.ebi.ac.uk/pdbsum/2p7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p7u OCA], [https://pdbe.org/2p7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p7u RCSB], [https://www.ebi.ac.uk/pdbsum/2p7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p7u ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q95PM0_TRYBR Q95PM0_TRYBR]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trybr]]
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[[Category: Trypanosoma brucei rhodesiense]]
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[[Category: Brinen, L S]]
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[[Category: Brinen LS]]
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[[Category: Marion, R]]
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[[Category: Marion R]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase]]
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[[Category: Neglected disease]]
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[[Category: Trypanosoma brucei]]
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Revision as of 10:57, 30 August 2023

The crystal structure of rhodesain, the major cysteine protease of T. brucei rhodesiense, bound to inhibitor K777

PDB ID 2p7u

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OCA

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