2pn8

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Current revision (11:05, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2pn8' size='340' side='right'caption='[[2pn8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2pn8' size='340' side='right'caption='[[2pn8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2pn8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PN8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2pn8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PN8 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDX4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pn8 OCA], [https://pdbe.org/2pn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2pn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pn8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pn8 OCA], [https://pdbe.org/2pn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2pn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pn8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PRDX4_HUMAN PRDX4_HUMAN]] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.<ref>PMID:9388242</ref>
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[https://www.uniprot.org/uniprot/PRDX4_HUMAN PRDX4_HUMAN] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.<ref>PMID:9388242</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peroxiredoxin]]
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[[Category: Arrowsmith CA]]
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[[Category: Arrowsmith, C A]]
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[[Category: Cooper C]]
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[[Category: Cooper, C]]
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[[Category: Edwards A]]
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[[Category: Delft, F von]]
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[[Category: Kavanagh KL]]
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[[Category: Edwards, A]]
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[[Category: Oppermann U]]
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[[Category: Kavanagh, K L]]
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[[Category: Pilka ES]]
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[[Category: Oppermann, U]]
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[[Category: Sundstrom M]]
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[[Category: Pilka, E S]]
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[[Category: Weigelt J]]
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[[Category: Structural genomic]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M]]
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[[Category: Weigelt, J]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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[[Category: Thioredoxin]]
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Current revision

Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)

PDB ID 2pn8

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