1mij
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1mij.gif|left|200px]] | [[Image:1mij.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1mij", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1mij| PDB=1mij | SCENE= }} | |
| - | | | + | |
| - | | | + | |
| - | }} | + | |
'''Crystal Structure of the Homeo-prospero Domain of D. melanogaster Prospero''' | '''Crystal Structure of the Homeo-prospero Domain of D. melanogaster Prospero''' | ||
| Line 29: | Line 26: | ||
[[Category: Ryter, J M.]] | [[Category: Ryter, J M.]] | ||
[[Category: 4-helix bundle]] | [[Category: 4-helix bundle]] | ||
| - | [[Category: | + | [[Category: Dna-binding domain]] |
| - | [[Category: | + | [[Category: Homeodomain]] |
| - | [[Category: | + | [[Category: Prospero domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:06:42 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 22:06, 2 May 2008
Crystal Structure of the Homeo-prospero Domain of D. melanogaster Prospero
Overview
The Prospero transcription factor promotes neural differentiation in Drosophila, and its activity is tightly regulated by modulating its subcellular localization. Prospero is exported from the nucleus of neural precursors but imported into the nucleus of daughter cells, which is necessary for their proper differentiation. Prospero has a highly divergent putative homeodomain adjacent to a conserved Prospero domain; both are required for sequence-specific DNA binding. Here we show that the structure of these two regions consists of a single structural unit (a homeo-prospero domain), in which the Prospero domain region is in position to contribute to DNA binding and also to mask a defined nuclear export signal that is within the putative homeodomain region. We propose that the homeo-prospero domain coordinately regulates Prospero nuclear localization and DNA binding specificity.
About this Structure
1MIJ is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
Structure of the DNA binding region of prospero reveals a novel homeo-prospero domain., Ryter JM, Doe CQ, Matthews BW, Structure. 2002 Nov;10(11):1541-9. PMID:12429095 Page seeded by OCA on Sat May 3 01:06:42 2008
