2pq5

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Current revision (11:06, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2pq5' size='340' side='right'caption='[[2pq5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2pq5' size='340' side='right'caption='[[2pq5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2pq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PQ5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2pq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PQ5 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gwo|2gwo]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP13, TMDP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pq5 OCA], [https://pdbe.org/2pq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pq5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pq5 OCA], [https://pdbe.org/2pq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pq5 RCSB], [https://www.ebi.ac.uk/pdbsum/2pq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pq5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DS13B_HUMAN DS13B_HUMAN]] Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.<ref>PMID:21360282</ref>
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[https://www.uniprot.org/uniprot/DS13B_HUMAN DS13B_HUMAN] Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.<ref>PMID:21360282</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[MAP kinase phosphatase|MAP kinase phosphatase]]
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*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Barr, A]]
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[[Category: Barr A]]
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[[Category: Berridge, G]]
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[[Category: Berridge G]]
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[[Category: Bunkoczi, G]]
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[[Category: Bunkoczi G]]
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[[Category: Burgess-Brown, N]]
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[[Category: Burgess-Brown N]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Niesen F]]
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[[Category: Niesen, F]]
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[[Category: Pantic N]]
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[[Category: Pantic, N]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W]]
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[[Category: Salah E]]
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[[Category: Structural genomic]]
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[[Category: Savitsky P]]
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[[Category: Salah, E]]
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[[Category: Sundstrom M]]
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[[Category: Savitsky, P]]
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[[Category: Ugochukwu E]]
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[[Category: Sundstrom, M]]
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[[Category: Uppenberg J]]
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[[Category: Ugochukwu, E]]
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[[Category: Weigelt J]]
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[[Category: Uppenberg, J]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Dual specificity phosphatase]]
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[[Category: Dusp13]]
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[[Category: Hydrolase]]
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[[Category: Protein phosphatase]]
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[[Category: Sgc]]
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[[Category: Testis and skeletal muscle specific dsp]]
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Current revision

Crystal structure of Dual specificity protein phosphatase 13 (DUSP13)

PDB ID 2pq5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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