2pxh

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Current revision (11:11, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2pxh' size='340' side='right'caption='[[2pxh]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
<StructureSection load='2pxh' size='340' side='right'caption='[[2pxh]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2pxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43067 Atcc 43067]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PXH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2pxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PXH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BP5:3-(2,2-BIPYRIDIN-5-YL)-L-ALANINE'>BP5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j1u|1j1u]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BP5:3-(2,2-BIPYRIDIN-5-YL)-L-ALANINE'>BP5</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tyrosyl-tRNA synthetase ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 ATCC 43067])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxh OCA], [https://pdbe.org/2pxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pxh RCSB], [https://www.ebi.ac.uk/pdbsum/2pxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pxh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxh OCA], [https://pdbe.org/2pxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pxh RCSB], [https://www.ebi.ac.uk/pdbsum/2pxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pxh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
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[https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 43067]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Methanocaldococcus jannaschii]]
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[[Category: Liu, W]]
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[[Category: Liu W]]
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[[Category: Schultz, P G]]
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[[Category: Schultz PG]]
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[[Category: Xie, J]]
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[[Category: Xie J]]
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[[Category: Bipyridylalanine]]
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[[Category: Ligase]]
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[[Category: Metal chelator]]
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[[Category: Unnatural amino acid]]
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Current revision

Crystal structure of a bipyridylalanyl-tRNA synthetase

PDB ID 2pxh

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