1mj4

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[[Image:1mj4.jpg|left|200px]]
[[Image:1mj4.jpg|left|200px]]
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{{Structure
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|PDB= 1mj4 |SIZE=350|CAPTION= <scene name='initialview01'>1mj4</scene>, resolution 1.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1mj4", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfite_oxidase Sulfite oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.1 1.8.3.1] </span>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1mj4| PDB=1mj4 | SCENE= }}
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|RELATEDENTRY=[[1sox|1SOX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mj4 OCA], [http://www.ebi.ac.uk/pdbsum/1mj4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mj4 RCSB]</span>
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'''Crystal Structure Analysis of the cytochrome b5 domain of human sulfite oxidase'''
'''Crystal Structure Analysis of the cytochrome b5 domain of human sulfite oxidase'''
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[[Category: Rajagopalan, K V.]]
[[Category: Rajagopalan, K V.]]
[[Category: Rudolph, M J.]]
[[Category: Rudolph, M J.]]
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[[Category: cytochrome b5]]
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[[Category: Cytochrome b5]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: sulfite oxidase]]
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[[Category: Sulfite oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:09:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:41 2008''
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Revision as of 22:09, 2 May 2008

Image:1mj4.jpg

Template:STRUCTURE 1mj4

Crystal Structure Analysis of the cytochrome b5 domain of human sulfite oxidase


Overview

The molybdenum- and iron-containing enzyme sulfite oxidase catalyzes the physiologically vital oxidation of sulfite to sulfate. Sulfite oxidase contains three domains: an N-terminal cytochrome b(5) domain, a central domain harboring the molybdenum cofactor (Moco) and a C-terminal dimerization domain. Oxidation of the substrate sulfite is coupled to the transfer of two electrons to the molybdenum cofactor. Subsequently, these electrons are passed on, one at a time, to the b(5) heme of sulfite oxidase and from there to the soluble electron carrier cytochrome c. The crystal structure of the oxidized human sulfite oxidase cytochrome b(5) domain has been determined at 1.2 A resolution and has been refined to a crystallographic R factor of 0.107 (R(free) = 0.137). A comparison of this structure with other b(5)-type cytochromes reveals distinct structural features present in the sulfite oxidase b(5) domain which promote optimal electron transport between the Moco of sulfite oxidase and the heme of cytochrome c.

About this Structure

1MJ4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain., Rudolph MJ, Johnson JL, Rajagopalan KV, Kisker C, Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1183-91. Epub 2003, Jun 27. PMID:12832761 Page seeded by OCA on Sat May 3 01:09:52 2008

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