2r9k

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<StructureSection load='2r9k' size='340' side='right'caption='[[2r9k]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2r9k' size='340' side='right'caption='[[2r9k]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/European_mistletoe European mistletoe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2r9k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m2t|1m2t]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SGI:3-(4-HYDROXYPHENYL)PROPANAMIDE'>SGI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [https://pdbe.org/2r9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [https://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9k OCA], [https://pdbe.org/2r9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9k RCSB], [https://www.ebi.ac.uk/pdbsum/2r9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL]] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
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[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: European mistletoe]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Betzel, C]]
 
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[[Category: Celewicz, L]]
 
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[[Category: Erdmann, V A]]
 
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[[Category: Meyer, A]]
 
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[[Category: Rypniewski, W]]
 
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[[Category: Voelter, W]]
 
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[[Category: Glycoprotein]]
 
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[[Category: Hydrolase]]
 
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[[Category: Lectin]]
 
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[[Category: Ml-i]]
 
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[[Category: Phloretamide]]
 
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[[Category: Plant defense]]
 
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[[Category: Protein synthesis inhibitor]]
 
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[[Category: Toxin]]
 
[[Category: Viscum album]]
[[Category: Viscum album]]
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[[Category: Betzel C]]
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[[Category: Celewicz L]]
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[[Category: Erdmann VA]]
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[[Category: Meyer A]]
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[[Category: Rypniewski W]]
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[[Category: Voelter W]]

Revision as of 11:50, 30 August 2023

Crystal Structure of Misteltoe Lectin I in Complex with Phloretamide

PDB ID 2r9k

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