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2rey
From Proteopedia
(Difference between revisions)
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<StructureSection load='2rey' size='340' side='right'caption='[[2rey]], [[Resolution|resolution]] 1.55Å' scene=''> | <StructureSection load='2rey' size='340' side='right'caption='[[2rey]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2rey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2rey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2REY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rey OCA], [https://pdbe.org/2rey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rey RCSB], [https://www.ebi.ac.uk/pdbsum/2rey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rey ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rey OCA], [https://pdbe.org/2rey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rey RCSB], [https://www.ebi.ac.uk/pdbsum/2rey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rey ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DVL2_HUMAN DVL2_HUMAN] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).<ref>PMID:19252499</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Cooper | + | [[Category: Cooper C]] |
| - | + | [[Category: Doyle D]] | |
| - | [[Category: Doyle | + | [[Category: Edwards AM]] |
| - | [[Category: Edwards | + | [[Category: Elkins J]] |
| - | [[Category: Elkins | + | [[Category: Gileadi C]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi O]] |
| - | [[Category: Gileadi | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Papagrigoriou | + | [[Category: Pike ACW]] |
| - | [[Category: Pike | + | [[Category: Sundstrom M]] |
| - | + | [[Category: Turnbull A]] | |
| - | [[Category: Sundstrom | + | [[Category: Ugochukwu E]] |
| - | [[Category: Turnbull | + | [[Category: Weigelt J]] |
| - | [[Category: Ugochukwu | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
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Current revision
Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Cooper C | Doyle D | Edwards AM | Elkins J | Gileadi C | Gileadi O | Papagrigoriou E | Pike ACW | Sundstrom M | Turnbull A | Ugochukwu E | Weigelt J | Von Delft F
