3bm6

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<StructureSection load='3bm6' size='340' side='right'caption='[[3bm6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3bm6' size='340' side='right'caption='[[3bm6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bm6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BM6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bm6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BM6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C9P:4-(DIHYDROXYBORANYL)-2-({[4-(PHENYLSULFONYL)THIOPHEN-2-YL]SULFONYL}AMINO)BENZOIC+ACID'>C9P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ga9|1ga9]], [[1c3b|1c3b]], [[2i72|2i72]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C9P:4-(DIHYDROXYBORANYL)-2-({[4-(PHENYLSULFONYL)THIOPHEN-2-YL]SULFONYL}AMINO)BENZOIC+ACID'>C9P</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ampC, ampA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bm6 OCA], [https://pdbe.org/3bm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bm6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bm6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bm6 OCA], [https://pdbe.org/3bm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bm6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bm6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tondi, D]]
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[[Category: Tondi D]]
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[[Category: Ampc]]
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[[Category: Antibiotic resistance]]
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[[Category: Cephalosporinase]]
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[[Category: Covalent inhibition]]
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[[Category: Hydrolase]]
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[[Category: Periplasm]]
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[[Category: Serine hydrolase]]
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Revision as of 12:10, 30 August 2023

AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid

PDB ID 3bm6

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