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3byi

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Current revision (12:18, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3byi' size='340' side='right'caption='[[3byi]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3byi' size='340' side='right'caption='[[3byi]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3byi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BYI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3byi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BYI FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGAP15 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3byi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3byi OCA], [https://pdbe.org/3byi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3byi RCSB], [https://www.ebi.ac.uk/pdbsum/3byi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3byi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3byi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3byi OCA], [https://pdbe.org/3byi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3byi RCSB], [https://www.ebi.ac.uk/pdbsum/3byi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3byi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RHG15_HUMAN RHG15_HUMAN]] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.<ref>PMID:12650940</ref>
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[https://www.uniprot.org/uniprot/RHG15_HUMAN RHG15_HUMAN] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.<ref>PMID:12650940</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Burgess-Brown, N]]
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[[Category: Burgess-Brown N]]
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[[Category: Delft, F von]]
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[[Category: Doyle D]]
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[[Category: Doyle, D]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Elkins J]]
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[[Category: Elkins, J]]
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[[Category: Johansson C]]
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[[Category: Johansson, C]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W]]
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[[Category: Shrestha L]]
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[[Category: Structural genomic]]
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[[Category: Tickle J]]
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[[Category: Shrestha, L]]
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[[Category: Ugochukwu E]]
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[[Category: Tickle, J]]
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[[Category: Uppenberg J]]
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[[Category: Ugochukwu, E]]
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[[Category: Weigelt J]]
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[[Category: Uppenberg, J]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J]]
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[[Category: Arhgap15]]
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[[Category: Bm046]]
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[[Category: Rho gtpase]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)

PDB ID 3byi

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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