1mke
From Proteopedia
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[[Image:1mke.jpg|left|200px]] | [[Image:1mke.jpg|left|200px]] | ||
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'''Structure of the N-WASP EVH1 Domain-WIP complex''' | '''Structure of the N-WASP EVH1 Domain-WIP complex''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MKE is a [[Single protein]] structure | + | 1MKE is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MKE OCA]. |
==Reference== | ==Reference== | ||
Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome., Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA, Cell. 2002 Nov 15;111(4):565-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12437929 12437929] | Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome., Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA, Cell. 2002 Nov 15;111(4):565-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12437929 12437929] | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Lim, W A.]] | [[Category: Lim, W A.]] | ||
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[[Category: Scott, J A.]] | [[Category: Scott, J A.]] | ||
[[Category: Volkman, B F.]] | [[Category: Volkman, B F.]] | ||
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Revision as of 22:17, 2 May 2008
Structure of the N-WASP EVH1 Domain-WIP complex
Overview
Missense mutants that cause the immune disorder Wiskott-Aldrich Syndrome (WAS) map primarily to the Enabled/VASP homology 1 (EVH1) domain of the actin regulatory protein WASP. This domain has been implicated in both peptide and phospholipid binding. We show here that the N-WASP EVH1 domain does not bind phosphatidyl inositol-(4,5)-bisphosphate, as previously reported, but does specifically bind a 25 residue motif from the WASP Interacting Protein (WIP). The NMR structure of the complex reveals a novel recognition mechanism-the WIP ligand, which is far longer than canonical EVH1 ligands, wraps around the domain, contacting a narrow but extended surface. This recognition mechanism provides a basis for understanding the effects of mutations that cause WAS.
About this Structure
1MKE is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome., Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA, Cell. 2002 Nov 15;111(4):565-76. PMID:12437929 Page seeded by OCA on Sat May 3 01:17:13 2008
