3cos

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Current revision (12:31, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3cos' size='340' side='right'caption='[[3cos]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3cos' size='340' side='right'caption='[[3cos]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3cos]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3cos]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADH4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cos OCA], [https://pdbe.org/3cos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cos RCSB], [https://www.ebi.ac.uk/pdbsum/3cos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cos ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cos OCA], [https://pdbe.org/3cos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cos RCSB], [https://www.ebi.ac.uk/pdbsum/3cos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cos ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ADH4_HUMAN ADH4_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alcohol dehydrogenase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bishop, S]]
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[[Category: Bishop S]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Kavanagh KL]]
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[[Category: Kavanagh, K L]]
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[[Category: Murray J]]
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[[Category: Murray, J]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Roos A]]
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[[Category: Roos, A]]
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[[Category: Shafqat N]]
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[[Category: Structural genomic]]
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[[Category: Yue W]]
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[[Category: Shafqat, N]]
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[[Category: Von Delft F]]
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[[Category: Yue, W]]
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[[Category: Medium chain dehydrogenase]]
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[[Category: Metal-binding]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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[[Category: Zinc-dependent]]
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Current revision

Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn

PDB ID 3cos

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