3d1e

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Current revision (12:37, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3d1e' size='340' side='right'caption='[[3d1e]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3d1e' size='340' side='right'caption='[[3d1e]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3d1e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D1E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3d1e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D1E FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2pol|2pol]], [[3bep|3bep]], [[3d1f|3d1f]], [[3d1g|3d1g]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d1e OCA], [https://pdbe.org/3d1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d1e RCSB], [https://www.ebi.ac.uk/pdbsum/3d1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d1e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d1e OCA], [https://pdbe.org/3d1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d1e RCSB], [https://www.ebi.ac.uk/pdbsum/3d1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d1e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
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[https://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3d1e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3d1e" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Donnell, M O]]
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[[Category: Georgescu RE]]
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[[Category: Georgescu, R E]]
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[[Category: Kong X-P]]
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[[Category: Kong, X P]]
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[[Category: Kuriyan J]]
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[[Category: Kuriyan, J]]
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[[Category: O'Donnell M]]
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[[Category: Seung-Sup, K]]
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[[Category: Seung-Sup K]]
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[[Category: Yurieva, O]]
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[[Category: Yurieva O]]
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[[Category: Antibiotic target]]
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[[Category: Chemical probe]]
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[[Category: Dna polymerase]]
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[[Category: Dna replication]]
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[[Category: Dna sliding clamp]]
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[[Category: Rational drug design]]
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[[Category: Transcription]]
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[[Category: Transferase]]
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Current revision

Crystal structure of E. coli sliding clamp (beta) bound to a polymerase II peptide

PDB ID 3d1e

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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