3d6h
From Proteopedia
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<StructureSection load='3d6h' size='340' side='right'caption='[[3d6h]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3d6h' size='340' side='right'caption='[[3d6h]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3d6h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3d6h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D6H FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CF0:FLUOROMETHANE'>CF0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr> | |
| - | <tr id=' | + | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6h OCA], [https://pdbe.org/3d6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d6h RCSB], [https://www.ebi.ac.uk/pdbsum/3d6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d6h ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d6h OCA], [https://pdbe.org/3d6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d6h RCSB], [https://www.ebi.ac.uk/pdbsum/3d6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d6h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Roesler | + | [[Category: Roesler J]] |
| - | [[Category: Romanowski | + | [[Category: Romanowski MJ]] |
| - | [[Category: Rosen-Wolff | + | [[Category: Rosen-Wolff A]] |
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Revision as of 12:41, 30 August 2023
Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
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