1mkz

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[[Image:1mkz.jpg|left|200px]]
[[Image:1mkz.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1mkz |SIZE=350|CAPTION= <scene name='initialview01'>1mkz</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1mkz", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= MoaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00886 MogA_MoaB]</span>
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{{STRUCTURE_1mkz| PDB=1mkz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mkz OCA], [http://www.ebi.ac.uk/pdbsum/1mkz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mkz RCSB]</span>
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}}
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'''Crystal structure of MoaB protein at 1.6 A resolution.'''
'''Crystal structure of MoaB protein at 1.6 A resolution.'''
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[[Category: Savchenko, A.]]
[[Category: Savchenko, A.]]
[[Category: Skarina, T.]]
[[Category: Skarina, T.]]
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[[Category: mad]]
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[[Category: Mad]]
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[[Category: mcsg]]
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[[Category: Mcsg]]
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[[Category: midwest center for structural genomic]]
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[[Category: Midwest center for structural genomic]]
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[[Category: molybdopterin synthesis]]
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[[Category: Molybdopterin synthesis]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: weak anomalous signal]]
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[[Category: Weak anomalous signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:20:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:17:27 2008''
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Revision as of 22:20, 2 May 2008

Image:1mkz.jpg

Template:STRUCTURE 1mkz

Crystal structure of MoaB protein at 1.6 A resolution.


Overview

The crystal structure of Escherichia coli MoaB was determined by multiwavelength anomalous diffraction phasing and refined at 1.6-A resolution. The molecule displayed a modified Rossman fold. MoaB is assembled into a hexamer composed of two trimers. The monomers have high structural similarity with two proteins, MogA and MoeA, from the molybdenum cofactor synthesis pathway in E. coli, as well as with domains of mammalian gephyrin and plant Cnx1, which are also involved in molybdopterin synthesis. Structural comparison between these proteins and the amino acid conservation patterns revealed a putative active site in MoaB. The structural analysis of this site allowed to advance several hypothesis that can be tested in further studies.

About this Structure

1MKZ is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of Escherichia coli MoaB suggests a probable role in molybdenum cofactor synthesis., Sanishvili R, Beasley S, Skarina T, Glesne D, Joachimiak A, Edwards A, Savchenko A, J Biol Chem. 2004 Oct 1;279(40):42139-46. Epub 2004 Jul 21. PMID:15269205 Page seeded by OCA on Sat May 3 01:20:49 2008

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