3dzi

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<StructureSection load='3dzi' size='340' side='right'caption='[[3dzi]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
<StructureSection load='3dzi' size='340' side='right'caption='[[3dzi]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3dzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DZI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3dzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DZI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene>, <scene name='pdbligand=RGT:2-AMINO-9-{5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-RIBOFURANOSYL}-9H-PURIN-6-YL+5-O-PHOSPHONO-BETA-D-RIBOFURANOSIDE'>RGT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dzf|3dzf]], [[3dzg|3dzg]], [[3dzh|3dzh]], [[3dzj|3dzj]], [[3dzk|3dzk]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene>, <scene name='pdbligand=RGT:2-AMINO-9-{5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-RIBOFURANOSYL}-9H-PURIN-6-YL+5-O-PHOSPHONO-BETA-D-RIBOFURANOSIDE'>RGT</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dzi OCA], [https://pdbe.org/3dzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dzi RCSB], [https://www.ebi.ac.uk/pdbsum/3dzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dzi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dzi OCA], [https://pdbe.org/3dzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dzi RCSB], [https://www.ebi.ac.uk/pdbsum/3dzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dzi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Graeff, R]]
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[[Category: Graeff R]]
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[[Category: Hao, Q]]
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[[Category: Hao Q]]
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[[Category: Jiang, H]]
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[[Category: Jiang H]]
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[[Category: Kriksunov, I A]]
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[[Category: Kriksunov IA]]
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[[Category: Lee, H C]]
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[[Category: Lee HC]]
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[[Category: Lin, H]]
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[[Category: Lin H]]
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[[Category: Liu, Q]]
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[[Category: Liu Q]]
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[[Category: Alpha bundle]]
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[[Category: Alternative splicing]]
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[[Category: Beta sheet]]
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[[Category: Diabetes mellitus]]
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[[Category: Glycoprotein]]
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[[Category: Gtp complex]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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[[Category: Nad]]
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[[Category: Noncovalent intermediate]]
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[[Category: Polymorphism]]
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[[Category: R5p-gtp adduct]]
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[[Category: Receptor]]
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[[Category: Signal-anchor]]
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[[Category: Transmembrane]]
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Revision as of 12:55, 30 August 2023

Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex

PDB ID 3dzi

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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