3e9j
From Proteopedia
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<StructureSection load='3e9j' size='340' side='right'caption='[[3e9j]], [[Resolution|resolution]] 3.70Å' scene=''> | <StructureSection load='3e9j' size='340' side='right'caption='[[3e9j]], [[Resolution|resolution]] 3.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3e9j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3e9j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E9J FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9j OCA], [https://pdbe.org/3e9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e9j RCSB], [https://www.ebi.ac.uk/pdbsum/3e9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e9j ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e9j OCA], [https://pdbe.org/3e9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e9j RCSB], [https://www.ebi.ac.uk/pdbsum/3e9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e9j ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | + | [https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Escherichia coli K-12]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Glockshuber | + | [[Category: Glockshuber R]] |
- | [[Category: Malojcic | + | [[Category: Malojcic G]] |
- | [[Category: Owen | + | [[Category: Owen RL]] |
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Revision as of 12:59, 30 August 2023
Structure of the charge-transfer intermediate of the transmembrane redox catalyst DsbB
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