3ej5

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Current revision (13:04, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3ej5' size='340' side='right'caption='[[3ej5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3ej5' size='340' side='right'caption='[[3ej5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ej5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Castor_bean Castor bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EJ5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ej5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EJ5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EJ5:4-[3-(2-AMINO-4-HYDROXY-6-OXO-1,6-DIHYDROPYRIMIDIN-5-YL)PROPYL]BENZOIC+ACID'>EJ5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EJ5:4-[3-(2-AMINO-4-HYDROXY-6-OXO-1,6-DIHYDROPYRIMIDIN-5-YL)PROPYL]BENZOIC+ACID'>EJ5</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ej5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ej5 OCA], [https://pdbe.org/3ej5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ej5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ej5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ej5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ej5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ej5 OCA], [https://pdbe.org/3ej5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ej5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ej5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ej5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
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[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Ricin|Ricin]]
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*[[Ricin 3D structures|Ricin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Castor bean]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RRNA N-glycosylase]]
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[[Category: Ricinus communis]]
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[[Category: Bai, Y]]
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[[Category: Bai Y]]
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[[Category: Monzingo, A F]]
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[[Category: Monzingo AF]]
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[[Category: Robertus, J D]]
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[[Category: Robertus JD]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Lectin]]
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[[Category: Nucleotide-binding]]
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[[Category: Plant defense]]
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[[Category: Protein inhibitor complex]]
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[[Category: Protein synthesis inhibitor]]
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[[Category: Toxin]]
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Current revision

complex of Ricin A chain and pyrimidine-based inhibitor

PDB ID 3ej5

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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