7mdn

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Current revision (13:11, 30 August 2023) (edit) (undo)
 
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==Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a==
==Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a==
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<StructureSection load='7mdn' size='340' side='right'caption='[[7mdn]]' scene=''>
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<StructureSection load='7mdn' size='340' side='right'caption='[[7mdn]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MDN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7mdn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MDN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mdn OCA], [https://pdbe.org/7mdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mdn RCSB], [https://www.ebi.ac.uk/pdbsum/7mdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mdn ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=Y6V:~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide'>Y6V</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mdn OCA], [https://pdbe.org/7mdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mdn RCSB], [https://www.ebi.ac.uk/pdbsum/7mdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mdn ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Wolf-Hirschhorn syndrome. A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH. WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
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== Function ==
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[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.<ref>PMID:11152655</ref> <ref>PMID:16115125</ref> <ref>PMID:18172012</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith CH]]

Current revision

Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a

PDB ID 7mdn

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