2yps
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2yps' size='340' side='right'caption='[[2yps]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2yps' size='340' side='right'caption='[[2yps]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yps]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2yps]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPS FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yps OCA], [https://pdbe.org/2yps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yps RCSB], [https://www.ebi.ac.uk/pdbsum/2yps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yps ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yps OCA], [https://pdbe.org/2yps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yps RCSB], [https://www.ebi.ac.uk/pdbsum/2yps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yps ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN] MMEP syndrome. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12). | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN] Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.<ref>PMID:11433298</ref> <ref>PMID:18767904</ref> | |
==See Also== | ==See Also== | ||
| Line 17: | Line 18: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Canning | + | [[Category: Canning P]] |
| - | + | [[Category: Edwards AM]] | |
| - | [[Category: Edwards | + | [[Category: Froese DS]] |
| - | [[Category: Froese | + | [[Category: Kiyani W]] |
| - | [[Category: Kiyani | + | [[Category: Krojer T]] |
| - | [[Category: Krojer | + | [[Category: Strain-Damerell C]] |
| - | [[Category: Strain-Damerell | + | [[Category: Yue WW]] |
| - | [[Category: Yue | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
Crystal structure of the PX domain of human sorting nexin 3
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Canning P | Edwards AM | Froese DS | Kiyani W | Krojer T | Strain-Damerell C | Yue WW | Von Delft F
