2yq3

Structural highlights

Function

POLG_BVDVS Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.[UniProtKB:P19712] Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Also plays a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.[UniProtKB:P19712] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans.[UniProtKB:P19711] E1 and/or E2 are probably responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis.[UniProtKB:P19711] E1 and/or E2 are probably responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis.[UniProtKB:P19711] Plays an essential role in the virus replication cycle by acting as a viroporin (By similarity). Forms ion conductive pores, which alters the cell permeability allowing the transport of ions and other small molecules (By similarity). Forms a leader sequence to properly orient NS2 in the membrane.[UniProtKB:P19712] Uncleaved NS2-3 is required for production of infectious virus. Plays a role in the regulation of viral RNA replication.[UniProtKB:P19712] Multifunctional protein that contains an N-terminal protease and a C-terminal helicase, playing essential roles in viral polyprotein processing and viral genome replication. The chymotrypsin-like serine protease activity utilizes NS4A as an essential cofactor and catalyzes the cleavage of the polyprotein leading to the release of NS4A, NS4B, NS5A, and NS5B. Interacts with NS5B to enhance RNA-dependent RNA polymerase activity.[UniProtKB:P19712] Acts as a cofactor for the NS3 protease activity.[UniProtKB:P19712] Induces a specific membrane alteration that serves as a scaffold for the virus replication complex.[UniProtKB:P19712] Replicates the viral (+) and (-) genome.

References

1. ↑ El Omari K, Iourin O, Harlos K, Grimes JM, Stuart DI. Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies Its Role in Cell Entry. Cell Rep. 2012 Dec 26. pii: S2211-1247(12)00424-X. doi:, 10.1016/j.celrep.2012.12.001. PMID:23273918 doi:http://dx.doi.org/10.1016/j.celrep.2012.12.001