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Poly(A) Polymerase

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</StructureSection>
</StructureSection>
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==3D structures of poly(A) polymerase==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Poly(A) polymerase
 
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**[[4lt6]] – hPAP-Υ – human<br />
 
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**[[3pq1]] – hPAP<br />
 
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**[[1q79]], [[1f5a]] - bPAP-α - bovine<br />
 
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**[[5a2v]] - cPAP – chicken<br />
 
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**[[2hhp]], [[2o1p]] – yPAP - yeast<BR />
 
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**[[7q73]] – fyPAP – fission yeast<BR />
 
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**[[7q74]] – fyPAP (mutant) <BR />
 
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**[[3aqk]], [[3aql]], [[3aqm]], [[3aqn]] – PAP residues 18-431 – ''Escherichia coli''<BR />
 
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**[[3owg]] – VvPAP catalytic subunit – Vaccinia virus<br />
 
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**[[3wfo]], [[3wfp]], [[4wby]], [[4wbz]] – AaPAP – ''Aquifex aeolicus''<br />
 
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**[[4zrl]] – PAP GLD2+GLD3 – ''Caenorhabditis elegans''<br />
 
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*Poly(A) polymerase complex with RNA
 
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**[[3er8]], [[3er9]], [[3erc]] – VvPAP VP55 + RNA<br />
 
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**[[1av6]] - VvPAP VP39 + SAH + RNA<br />
 
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**[[3wfq]], [[3wfr]], [[3wfs]], [[4wc3]], [[4wc4]], [[4wc5]], [[4wc6]], [[4wc7]], [[4x0a]], [[4x0b]] - AaPAP + RNA<br />
 
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**[[4wc2]] - AaPAP + RNA + ATP analog<br />
 
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*Poly(A) polymerase other complexes
 
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**[[1q78]] – bPAP-α + Mg + ATP<BR />
 
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**[[5a2y]], [[5a2z]], [[5a2x]], [[5a2w]] - cPAP + nucleotide <br />
 
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**[[5a30]] - cPAP (mutant) + nucleotide <br />
 
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**[[3c66]] - yPAP residues 1-526 + Fip1 peptide <BR />
 
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**[[2q66]] – yPAP + polyA + ATP<BR />
 
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**[[1fa0]] - yPAP + Mn + ATP<br />
 
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**[[7q72]] - fyPAP + Red1<br />
 
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**[[2ga9]] - VvPAP VP55 + VP39 + ATP<BR />
 
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**[[2gaf]] - VvPAP VP55 (mutant) + VP39<BR />
 
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**[[1jtf]], [[2vp3]] - VvPAP VP39 residues 1-307 (mutant) + M7GPPPG + SAH<BR />
 
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**[[1b42]], [[1bky]], [[1eqa]], [[3mag]], [[3mct]], [[4dcg]], [[1av6]], [[1p39]], [[1v39]]. [[1jsz]] - VvPAP VP39 residues 1-297 (mutant) + purine derivative + SAH<BR />
 
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**[[1vp3]] - VvPAP VP39 + SAH<BR />
 
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**[[1vp9]], [[1eam]], [[1jte]] - VvPAP VP39 (mutant) + SAH<BR />
 
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**[[1vpt]] - VvPAP VP39 (mutant) + SAM<BR />
 
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**[[4wc0]], [[4wc1]] - AaPAP + nucleotide<br />
 
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*Speckle targeted PIP5K1A-regulated poly(A) polymerase – STAR-PAP
 
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**[[5wu1]], [[5wu5]], [[5wu6]] – hSTAR-PAP (mutant)<br />
 
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**[[5wu2]], [[5wu3]], [[5wu4]] – hSTAR-PAP (mutant) + UTP<br />
 
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}}
 
Note: the regulatory subunit of Vaccinia virus Poly(A) polymerase is called '''VP39''' and the catalytic subunit name is '''VP55'''
Note: the regulatory subunit of Vaccinia virus Poly(A) polymerase is called '''VP39''' and the catalytic subunit name is '''VP55'''

Revision as of 09:14, 3 September 2023

Structure of Yeast Poly(A) Polymerase with ATP, Mg+2 ion (green) and oligo(A) (PDB entry 2q66)

Drag the structure with the mouse to rotate

Note: the regulatory subunit of Vaccinia virus Poly(A) polymerase is called VP39 and the catalytic subunit name is VP55

Additional Resources

For additional information, see: Translation
For additional examples of transferases, see: Transferase

Reference

Mechanism of poly(A) polymerase: structure of the enzyme-MgATP-RNA ternary complex and kinetic analysis., Balbo PB, Bohm A, Structure. 2007 Sep;15(9):1117-31. PMID:17850751

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