1ms6

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Revision as of 16:08, 12 November 2007

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spinqualitylabelsall models 1ms6, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Dipeptide Nitrile Inhibitor Bound to Cathepsin S.

Overview

The specificity of the immune response relies on processing of foreign, proteins and presentation of antigenic peptides at the cell surface., Inhibition of antigen presentation, and the subsequent activation of, T-cells, should, in theory, modulate the immune response. The cysteine, protease Cathepsin S performs a fundamental step in antigen presentation, and therefore represents an attractive target for inhibition. Herein, we, report a series of potent and reversible Cathepsin S inhibitors based on, dipeptide nitriles. These inhibitors show nanomolar inhibition of the, target enzyme as well as cellular potency in a human B cell line. The, first X-ray crystal structure of a reversible inhibitor cocrystallized, with Cathepsin S is also reported.

About this Structure

1MS6 is a Single protein structure of sequence from Homo sapiens with BLN as ligand. Active as Cathepsin S, with EC number 3.4.22.27 Full crystallographic information is available from OCA.

Reference

Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors., Ward YD, Thomson DS, Frye LL, Cywin CL, Morwick T, Emmanuel MJ, Zindell R, McNeil D, Bekkali Y, Girardot M, Hrapchak M, DeTuri M, Crane K, White D, Pav S, Wang Y, Hao MH, Grygon CA, Labadia ME, Freeman DM, Davidson W, Hopkins JL, Brown ML, Spero DM, J Med Chem. 2002 Dec 5;45(25):5471-82. PMID:12459015

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