1mmj

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[[Image:1mmj.gif|left|200px]]
[[Image:1mmj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mmj |SIZE=350|CAPTION= <scene name='initialview01'>1mmj</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1mmj", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FR1:2-[4-[[(S)-1-[[(S)-2-[[(RS)-3,3,3-TRIFLUORO-1-ISOPROPYL-2-OXOPROPYL]AMINOCARBONYL]PYRROLIDIN-1-YL-]CARBONYL]-2-METHYLPROPYL]AMINOCARBONYL]BENZOYLAMINO]ACETIC+ACID'>FR1</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1mmj| PDB=1mmj | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mmj OCA], [http://www.ebi.ac.uk/pdbsum/1mmj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mmj RCSB]</span>
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}}
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'''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706'''
'''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706'''
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Kinoshita, T.]]
[[Category: Kinoshita, T.]]
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[[Category: chymotrypsin family]]
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[[Category: Chymotrypsin family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:25:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:18:09 2008''
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Revision as of 22:25, 2 May 2008

Image:1mmj.gif

Template:STRUCTURE 1mmj

Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706


Overview

The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.

About this Structure

1MMJ is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor., Kinoshita T, Nakanishi I, Sato A, Tada T, Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. PMID:12467609 Page seeded by OCA on Sat May 3 01:25:17 2008

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OCA

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