1mms

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[[Image:1mms.gif|left|200px]]
[[Image:1mms.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1mms", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MMC:METHYL+MERCURY+ION'>MMC</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1mms| PDB=1mms | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mms OCA], [http://www.ebi.ac.uk/pdbsum/1mms PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mms RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE RIBOSOMAL PROTEIN L11-RNA COMPLEX'''
'''CRYSTAL STRUCTURE OF THE RIBOSOMAL PROTEIN L11-RNA COMPLEX'''
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[[Category: White, S W.]]
[[Category: White, S W.]]
[[Category: Wimberly, B T.]]
[[Category: Wimberly, B T.]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: rna-protein complex]]
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[[Category: Rna-protein complex]]
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[[Category: thiostrepton]]
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[[Category: Thiostrepton]]
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[[Category: translocation]]
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[[Category: Translocation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:25:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:18:10 2008''
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Revision as of 22:25, 2 May 2008

Image:1mms.gif

Template:STRUCTURE 1mms

CRYSTAL STRUCTURE OF THE RIBOSOMAL PROTEIN L11-RNA COMPLEX


Overview

We report the crystal structure of a 58 nucleotide fragment of 23S ribosomal RNA bound to ribosomal protein L11. This highly conserved ribonucleoprotein domain is the target for the thiostrepton family of antibiotics that disrupt elongation factor function. The highly compact RNA has both familiar and novel structural motifs. While the C-terminal domain of L11 binds RNA tightly, the N-terminal domain makes only limited contacts with RNA and is proposed to function as a switch that reversibly associates with an adjacent region of RNA. The sites of mutations conferring resistance to thiostrepton and micrococcin line a narrow cleft between the RNA and the N-terminal domain. These antibiotics are proposed to bind in this cleft, locking the putative switch and interfering with the function of elongation factors.

About this Structure

1MMS is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

A detailed view of a ribosomal active site: the structure of the L11-RNA complex., Wimberly BT, Guymon R, McCutcheon JP, White SW, Ramakrishnan V, Cell. 1999 May 14;97(4):491-502. PMID:10338213 Page seeded by OCA on Sat May 3 01:25:55 2008

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