1msz

From Proteopedia

Revision as of 16:08, 12 November 2007

Solution structure of the R3H domain from human Smubp-2

Overview

The R3H domain is a conserved sequence motif, identified in over 100, proteins, that is thought to be involved in polynucleotide-binding, including DNA, RNA and single-stranded DNA. In this work the 3D structure, of the R3H domain from human Smubp-2 was determined by NMR spectroscopy., It is the first 3D structure determination of an R3H domain. The fold, presents a small motif, consisting of a three-stranded antiparallel, beta-sheet and two alpha-helices, which is related to the structures of, the YhhP protein and the C-terminal domain of the translational initiation, factor IF3. The similarities are non-trivial, as the amino acid identities, are below 10%. Three conserved basic residues cluster on the same face of, the R3H domain and could play a role in nucleic acid recognition. An, extended hydrophobic area at a different site of the molecular surface, could act as a protein-binding site. A strong correlation between, conservation of hydrophobic amino acids and side-chain solvent protection, indicates that the structure of the Smubp-2 R3H domain is representative, of R3H domains in general.

Disease

Known diseases associated with this structure: Neuronopathy, distal hereditary motor, type VI OMIM:[600502]

About this Structure

1MSZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of the R3H domain from human Smubp-2., Liepinsh E, Leonchiks A, Sharipo A, Guignard L, Otting G, J Mol Biol. 2003 Feb 7;326(1):217-23. PMID:12547203

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