1mn3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1mn3.jpg|left|200px]]
[[Image:1mn3.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1mn3 |SIZE=350|CAPTION= <scene name='initialview01'>1mn3</scene>, resolution 2.3&Aring;
+
The line below this paragraph, containing "STRUCTURE_1mn3", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= VPS9 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1mn3| PDB=1mn3 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mn3 OCA], [http://www.ebi.ac.uk/pdbsum/1mn3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mn3 RCSB]</span>
+
-
}}
+
'''Cue domain of yeast Vps9p'''
'''Cue domain of yeast Vps9p'''
Line 32: Line 29:
[[Category: Misra, S.]]
[[Category: Misra, S.]]
[[Category: Prag, G.]]
[[Category: Prag, G.]]
-
[[Category: ubiquitin]]
+
[[Category: Ubiquitin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:26:40 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:18:19 2008''
+

Revision as of 22:26, 2 May 2008

Image:1mn3.jpg

Template:STRUCTURE 1mn3

Cue domain of yeast Vps9p


Overview

Coupling of ubiquitin conjugation to ER degradation (CUE) domains are approximately 50 amino acid monoubiquitin binding motifs found in proteins of trafficking and ubiquitination pathways. The 2.3 A structure of the Vps9p-CUE domain is a dimeric domain-swapped variant of the ubiquitin binding UBA domain. The 1.7 A structure of the CUE:ubiquitin complex shows that one CUE dimer binds one ubiquitin molecule. The bound CUE dimer is kinked relative to the unbound CUE dimer and wraps around ubiquitin. The CUE monomer contains two ubiquitin binding surfaces on opposite faces of the molecule that cannot bind simultaneously to a single ubiquitin molecule. Dimerization of the CUE domain allows both surfaces to contact a single ubiquitin molecule, providing a mechanism for high-affinity binding to monoubiquitin.

About this Structure

1MN3 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Mechanism of ubiquitin recognition by the CUE domain of Vps9p., Prag G, Misra S, Jones EA, Ghirlando R, Davies BA, Horazdovsky BF, Hurley JH, Cell. 2003 May 30;113(5):609-20. PMID:12787502 Page seeded by OCA on Sat May 3 01:26:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mn3"
Personal tools