1mn8
From Proteopedia
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'''Structure of Moloney Murine Leukaemia Virus Matrix Protein''' | '''Structure of Moloney Murine Leukaemia Virus Matrix Protein''' | ||
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[[Category: Riffel, N.]] | [[Category: Riffel, N.]] | ||
[[Category: Stuart, D.]] | [[Category: Stuart, D.]] | ||
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Revision as of 22:26, 2 May 2008
Structure of Moloney Murine Leukaemia Virus Matrix Protein
Overview
Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins.
About this Structure
1MN8 is a Single protein structure of sequence from Moloney murine leukemia virus. Full crystallographic information is available from OCA.
Reference
Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins., Riffel N, Harlos K, Iourin O, Rao Z, Kingsman A, Stuart D, Fry E, Structure. 2002 Dec;10(12):1627-36. PMID:12467570 Page seeded by OCA on Sat May 3 01:26:44 2008
