8gq6

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'''Unreleased structure'''
 
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The entry 8gq6 is ON HOLD until Paper Publication
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==Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex==
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<StructureSection load='8gq6' size='340' side='right'caption='[[8gq6]], [[Resolution|resolution]] 3.96&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gq6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GQ6 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.96&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gq6 OCA], [https://pdbe.org/8gq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gq6 RCSB], [https://www.ebi.ac.uk/pdbsum/8gq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gq6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KBTB2_HUMAN KBTB2_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation.<ref>PMID:27708159</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen Z]]
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[[Category: Hu Y]]
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[[Category: Mao Q]]
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[[Category: Sun L]]

Revision as of 06:22, 6 September 2023

Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex

PDB ID 8gq6

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