8t0m
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Proteasome 20S core particle from Pre1-1 Pre4-1 Double mutant== | |
| - | + | <StructureSection load='8t0m' size='340' side='right'caption='[[8t0m]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8t0m]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T0M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t0m OCA], [https://pdbe.org/8t0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t0m RCSB], [https://www.ebi.ac.uk/pdbsum/8t0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t0m ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PSA4_YEAST PSA4_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Hanna J]] | ||
| + | [[Category: Rawson S]] | ||
| + | [[Category: Schnell H]] | ||
| + | [[Category: Velez B]] | ||
| + | [[Category: Walsh Jr RM]] | ||
Revision as of 06:28, 6 September 2023
Proteasome 20S core particle from Pre1-1 Pre4-1 Double mutant
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