8u0g

Structural highlights

Function

DDRC_DEIRA Appears to contribute to D.radiodurans capacity to survive exposure to ionizing radiation (PubMed:15454524). Likely functions as a DNA damage-induced nucleoid-associated protein (NAP) that contributes to the enhanced level of nucleoid compaction after irradiation by bridging DNA duplexes, thereby limiting the dispersion of the fragmented genome immediately after irradiation to facilitate subsequent DNA repair. In vitro, binds both ssDNA and dsDNA, and is able to compact circular DNA, circularize linear DNA, anneal complementary DNA strands and protect DNA from nucleases (PubMed:35801857, PubMed:28542368).^{[1] [2] [3]}

References

1. ↑ Tanaka M, Earl AM, Howell HA, Park MJ, Eisen JA, Peterson SN, Battista JR. Analysis of Deinococcus radiodurans's transcriptional response to ionizing radiation and desiccation reveals novel proteins that contribute to extreme radioresistance. Genetics. 2004 Sep;168(1):21-33. PMID:15454524 doi:http://dx.doi.org/10.1534/genetics.104.029249
2. ↑ Bouthier de la Tour C, Mathieu M, Meyer L, Dupaigne P, Passot F, Servant P, Sommer S, Le Cam E, Confalonieri F. In vivo and in vitro characterization of DdrC, a DNA damage response protein in Deinococcus radiodurans bacterium. PLoS One. 2017 May 18;12(5):e0177751. PMID:28542368 doi:10.1371/journal.pone.0177751
3. ↑ Banneville AS, Bouthier de la Tour C, De Bonis S, Hognon C, Colletier JP, Teulon JM, Le Roy A, Pellequer JL, Monari A, Dehez F, Confalonieri F, Servant P, Timmins J. Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction. Nucleic Acids Res. 2022 Jul 8. pii: 6633903. doi: 10.1093/nar/gkac563. PMID:35801857 doi:http://dx.doi.org/10.1093/nar/gkac563