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1mnm

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[[Image:1mnm.gif|left|200px]]
[[Image:1mnm.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mnm OCA], [http://www.ebi.ac.uk/pdbsum/1mnm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mnm RCSB]</span>
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'''YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE'''
'''YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE'''
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Tan, T J.Richmond S.]]
[[Category: Tan, T J.Richmond S.]]
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[[Category: complex (transcription/homeobox/dna)]]
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[[Category: Dna-binding protein]]
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[[Category: dna-binding protein]]
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[[Category: Transcription regulation]]
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[[Category: transcription regulation]]
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[[Category: Transcriptional repression]]
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[[Category: transcriptional repression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:27:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:18:30 2008''
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Revision as of 22:27, 2 May 2008

Image:1mnm.gif


PDB ID 1mnm

Drag the structure with the mouse to rotate
1mnm, resolution 2.25Å ()
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE


Overview

The structure of a complex containing the homeodomain repressor protein MATalpha2 and the MADS-box transcription factor MCM1 bound to DNA has been determined by X-ray crystallography at 2.25 A resolution. It reveals the protein-protein interactions responsible for cooperative binding of MATalpha2 and MCM1 to DNA. The otherwise flexible amino-terminal extension of the MATalpha2 homeodomain forms a beta-hairpin that grips the MCM1 surface through parallel beta-strand hydrogen bonds and close-packed, predominantly hydrophobic, side chains. DNA bending induced by MCM1 brings the two proteins closer together, facilitating their interaction. An unusual feature of the complex is that an eight-amino-acid sequence adopts an alpha-helical conformation in one of two copies of the MATalpha2 monomer and a beta-strand conformation in the other. This 'chameleon' sequence of MATalpha2 may be important for recognizing natural operator sites.

About this Structure

1MNM is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex., Tan S, Richmond TJ, Nature. 1998 Feb 12;391(6668):660-6. PMID:9490409 Page seeded by OCA on Sat May 3 01:27:55 2008

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