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3f0a
From Proteopedia
(Difference between revisions)
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<StructureSection load='3f0a' size='340' side='right'caption='[[3f0a]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3f0a' size='340' side='right'caption='[[3f0a]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3f0a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3f0a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F0A FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> |
| - | < | + | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0a OCA], [https://pdbe.org/3f0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f0a RCSB], [https://www.ebi.ac.uk/pdbsum/3f0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0a ProSAT], [https://www.topsan.org/Proteins/MCSG/3f0a TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f0a OCA], [https://pdbe.org/3f0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f0a RCSB], [https://www.ebi.ac.uk/pdbsum/3f0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f0a ProSAT], [https://www.topsan.org/Proteins/MCSG/3f0a TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PAIA_THEAC PAIA_THEAC] Involved in the protection against polyamine toxicity by regulating their concentration. Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product. It can use a variety of substrates including spermidine, L-tryptophan, L-leucine, L-lysine, dopamine and tyramine.<ref>PMID:21633970</ref> <ref>PMID:23184347</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Anderson, W F]] | ||
| - | [[Category: Clancy, S]] | ||
| - | [[Category: Filippova, E V]] | ||
| - | [[Category: Joachimiak, A]] | ||
| - | [[Category: Kiryukhina, O]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Minasov, G]] | ||
| - | [[Category: Shuvalova, L]] | ||
| - | [[Category: Acetyl-coa]] | ||
| - | [[Category: Mcsg]] | ||
| - | [[Category: N-acetyltransferase]] | ||
| - | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Thermoplasma acidophilum]] | [[Category: Thermoplasma acidophilum]] | ||
| - | [[Category: | + | [[Category: Anderson WF]] |
| + | [[Category: Clancy S]] | ||
| + | [[Category: Filippova EV]] | ||
| + | [[Category: Joachimiak A]] | ||
| + | [[Category: Kiryukhina O]] | ||
| + | [[Category: Minasov G]] | ||
| + | [[Category: Shuvalova L]] | ||
Current revision
Structure of a putative n-acetyltransferase (ta0374) in complex with acetyl-coa from thermoplasma acidophilum
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