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3f2c

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Current revision (06:40, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3f2c' size='340' side='right'caption='[[3f2c]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3f2c' size='340' side='right'caption='[[3f2c]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f2c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_kaustophilus"_prickett_1928 "bacillus kaustophilus" prickett 1928]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f2c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus Geobacillus kaustophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F2C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3f2b|3f2b]], [[3f2d|3f2d]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGT:2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>DGT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2c OCA], [https://pdbe.org/3f2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2c RCSB], [https://www.ebi.ac.uk/pdbsum/3f2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2c OCA], [https://pdbe.org/3f2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f2c RCSB], [https://www.ebi.ac.uk/pdbsum/3f2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f2c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Q5L0J3_GEOKA Q5L0J3_GEOKA]] Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).[HAMAP-Rule:MF_00356][SAAS:SAAS029460_004_008054]
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[https://www.uniprot.org/uniprot/Q5L0J3_GEOKA Q5L0J3_GEOKA] Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).[HAMAP-Rule:MF_00356][SAAS:SAAS029460_004_008054]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3f2c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3f2c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus kaustophilus prickett 1928]]
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[[Category: Geobacillus kaustophilus]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bullard, J M]]
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[[Category: Bullard JM]]
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[[Category: Christensen, J]]
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[[Category: Christensen J]]
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[[Category: Davies, D R]]
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[[Category: Davies DR]]
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[[Category: Evans, R J]]
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[[Category: Evans RJ]]
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[[Category: Green, L S]]
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[[Category: Green LS]]
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[[Category: Guiles, J W]]
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[[Category: Guiles JW]]
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[[Category: Janjic, N]]
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[[Category: Janjic N]]
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[[Category: Jarvis, T C]]
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[[Category: Jarvis TC]]
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[[Category: Ribble, W K]]
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[[Category: Ribble WK]]
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[[Category: Dna polymerase c]]
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[[Category: Dna polymerase iii]]
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[[Category: Gram-positive]]
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[[Category: Protein-dna complex]]
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[[Category: Replicative polymerase]]
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[[Category: Ternary complex]]
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[[Category: Transferase-dna complex]]
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Current revision

DNA Polymerase PolC from Geobacillus kaustophilus complex with DNA, dGTP and Mn

PDB ID 3f2c

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OCA

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