3f4n

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Current revision (06:42, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3f4n' size='340' side='right'caption='[[3f4n]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3f4n' size='340' side='right'caption='[[3f4n]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3f4n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F4N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3f4n]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F4N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PXP:PYRIDOXINE-5-PHOSPHATE'>PXP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.402&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pdxJ, y1300, YPO2930, YP_2525 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PXP:PYRIDOXINE-5-PHOSPHATE'>PXP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pyridoxine_5'-phosphate_synthase Pyridoxine 5'-phosphate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.99.2 2.6.99.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4n OCA], [https://pdbe.org/3f4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f4n RCSB], [https://www.ebi.ac.uk/pdbsum/3f4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4n ProSAT], [https://www.topsan.org/Proteins/CSGID/3f4n TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f4n OCA], [https://pdbe.org/3f4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f4n RCSB], [https://www.ebi.ac.uk/pdbsum/3f4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f4n ProSAT], [https://www.topsan.org/Proteins/CSGID/3f4n TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PDXJ_YERPE PDXJ_YERPE]] Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
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[https://www.uniprot.org/uniprot/PDXJ_YERPE PDXJ_YERPE] Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pyridoxine 5'-phosphate synthase]]
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[[Category: Yersinia pestis]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Structural genomic]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A]]
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[[Category: Kim Y]]
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[[Category: Kim, Y]]
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[[Category: Maltseva N]]
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[[Category: Maltseva, N]]
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[[Category: Stam J]]
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[[Category: Stam, J]]
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[[Category: Biosynthetic protein]]
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[[Category: Csgid]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Octamer]]
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[[Category: Pyridoxine biosynthesis]]
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[[Category: Tim barrel]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Pyridoxal Phosphate Biosynthetic Protein PdxJ from Yersinia pestis

PDB ID 3f4n

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