3fb8

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<StructureSection load='3fb8' size='340' side='right'caption='[[3fb8]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='3fb8' size='340' side='right'caption='[[3fb8]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fb8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FB8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fb8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FB8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3f5w|3f5w]], [[3f7v|3f7v]], [[3f7y|3f7y]], [[3fb5|3fb5]], [[3fb6|3fb6]], [[3fb7|3fb7]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 "Actinomyces lividans" Krasil'nikov et al. 1965])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb8 OCA], [https://pdbe.org/3fb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb8 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb8 OCA], [https://pdbe.org/3fb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fb8 RCSB], [https://www.ebi.ac.uk/pdbsum/3fb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
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[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cortes, D M]]
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[[Category: Streptomyces lividans]]
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[[Category: Cuello, L G]]
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[[Category: Cortes DM]]
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[[Category: Jogini, V]]
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[[Category: Cuello LG]]
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[[Category: Perozo, E]]
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[[Category: Jogini V]]
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[[Category: Cell membrane]]
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[[Category: Perozo E]]
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[[Category: Inactivation]]
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[[Category: Ion transport]]
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[[Category: Ionic channel]]
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[[Category: Kcsa]]
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[[Category: Membrane]]
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[[Category: Membrane protein-metal transport complex]]
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[[Category: Open]]
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[[Category: Potassium channel]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Voltage-gated channel]]
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Revision as of 06:44, 6 September 2023

KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion

PDB ID 3fb8

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