3fkc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:47, 6 September 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3fkc' size='340' side='right'caption='[[3fkc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3fkc' size='340' side='right'caption='[[3fkc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3fkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKC FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3fkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKC FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAISO, ZBTB33, ZNF348 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fkc OCA], [https://pdbe.org/3fkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fkc RCSB], [https://www.ebi.ac.uk/pdbsum/3fkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fkc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fkc OCA], [https://pdbe.org/3fkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fkc RCSB], [https://www.ebi.ac.uk/pdbsum/3fkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fkc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN]] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>
+
[https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 23: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bountra, C]]
+
[[Category: Bountra C]]
-
[[Category: Bullock, A]]
+
[[Category: Bullock A]]
-
[[Category: Burgess-Brown, N]]
+
[[Category: Burgess-Brown N]]
-
[[Category: Delft, F von]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M]]
+
[[Category: Filippakopoulos P]]
-
[[Category: Filippakopoulos, P]]
+
[[Category: Keates T]]
-
[[Category: Keates, T]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S]]
+
[[Category: Muniz J]]
-
[[Category: Muniz, J]]
+
[[Category: Weigelt J]]
-
[[Category: Structural genomic]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J]]
+
-
[[Category: Activator]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Kaiso transcription factor]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Repressor]]
+
-
[[Category: Sgc]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Wnt signaling pathway]]
+
-
[[Category: Wugsc:h_dj525n14 1]]
+
-
[[Category: Zinc finger and btb domain containing 33]]
+
-
[[Category: Zinc-finger]]
+
-
[[Category: Znf-kaiso]]
+
-
[[Category: Znf348]]
+

Current revision

Crystal Structure of Human Zinc finger and BTB domain containing 33

PDB ID 3fkc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fkc"
Personal tools