3gfc
From Proteopedia
(Difference between revisions)
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<StructureSection load='3gfc' size='340' side='right'caption='[[3gfc]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3gfc' size='340' side='right'caption='[[3gfc]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3gfc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3gfc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GFC FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gfc OCA], [https://pdbe.org/3gfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gfc RCSB], [https://www.ebi.ac.uk/pdbsum/3gfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gfc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gfc OCA], [https://pdbe.org/3gfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gfc RCSB], [https://www.ebi.ac.uk/pdbsum/3gfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gfc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | + | [https://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Amaya | + | [[Category: Amaya MF]] |
- | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
- | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
- | [[Category: Bountra | + | [[Category: Bountra C]] |
- | [[Category: Dong | + | [[Category: Dong A]] |
- | [[Category: Edwards | + | [[Category: Edwards AM]] |
- | [[Category: He | + | [[Category: He H]] |
- | [[Category: Li | + | [[Category: Li Z]] |
- | [[Category: Min | + | [[Category: Min J]] |
- | [[Category: Ni | + | [[Category: Ni S]] |
- | [[Category: Ouyang | + | [[Category: Ouyang H]] |
- | + | [[Category: Weigelt J]] | |
- | [[Category: Weigelt | + | |
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Current revision
Crystal Structure of Histone-binding protein RBBP4
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Categories: Homo sapiens | Large Structures | Amaya MF | Arrowsmith CH | Bochkarev A | Bountra C | Dong A | Edwards AM | He H | Li Z | Min J | Ni S | Ouyang H | Weigelt J